Abstract
Cisplatin drug is one of platinum compounds and it is in common use world wide for the treatment of a variety of human neoplasms. However in high doses it can produce undesirable toxic side effects on liver, so in this study we investigated whether vitamin C has protective effect on hepatotoxicity induced by cisplatin or not. Three equal-sized groups (six rats each) of adult male albino rats were used as a)- control group b)- recipient of cisplatin or c)- recipient of vitamin C, 24 hrs before cisplatin injection. Histological examination of livers were carried out using light microscopy. Results showed that cisplatin produced pathological changes manifested as severe fatty changes, congestion and dilatation of portal blood vessels and central veins, dilatation and congestion of sinusoids, with multiple necrotic foci and apoptotic cells, while prior administration of vitamin C produced amelioration of the pathological changes induced by cisplatin.
Highlights
Cisplatin drug is one of platinum compounds and it is in common use world wide for the treatment of a variety of human neoplasms
The proposed plan aimed to asses and examine the possibility of vitamin C, through its antioxidant property, to protect against and reduce the histopathological changes induced by cisplatin on normal liver tissues of male albino rats, which were used as biological test animals
The liver tissues of the control group in the present study revealed no deviation from the normal histological structure
Summary
Cisplatin drug is one of platinum compounds and it is in common use world wide for the treatment of a variety of human neoplasms. The proposed plan aimed to asses and examine the possibility of vitamin C, through its antioxidant property, to protect against and reduce the histopathological changes induced by cisplatin on normal liver tissues of male albino rats, which were used as biological test animals.
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