Effect of vinpocetine combined with butylphthalide in the treatment of atherosclerotic cerebral infarction

Abstract

Objective To observe the effect of vinpocetine combined with butylphthalide in the treatment of large artery atherosclerotic infarction. Methods From October 2014 to October 2016, Ninety patients with large artery atherosclerotic cerebral infarction in Datong Coal Mine Group Three Hospital were selected and randomly divided into two groups, with 45 cases in each group.The treatment group was given vinpocetine injection, and the observation group was given vinpocetine injection combined with butylphthalide soft capsules.The ability of daily life (Barthel) score, neurological deficit score(NIHSS), hemodynamics indicators[ high blood viscosity (HSV), plasma viscosity index(PSV)] and adverse reactions were compared between the two groups. Results After treatment, the Barthel score, NIHSS score of the observation group were (79.84±18.57)points, (9.54±3.22)points, respectively, which of the control group were (62.67±16.48)points, (13.69±3.47)points, respectively, there were statistically significant differences between the two groups(t=4.64, 5.88, all P<0.05). The HSV, PSV of the observation group were (3.96±2.14)mPa/s, (1.12±0.74)mPa/s, respectively, which of the control group were (5.77±2.69)mPa/s, (3.10±1.02)mPa/s, respectively, there were statistically significant differences between the two groups(t=3.53, 10.54, all P<0.05). The incidence rate of adverse reactions of the observation group was 4.44%, which was lower than 17.78% of the control group, the difference was statistically significant (χ2=4.05, P=0.04). Conclusion Vinpocetine injection combined with butylphthalide soft capsules in the treatment of large artery atherosclerotic infarction can improve neurological function and hemodynamics, the effect is superior to single vinpocetine treatment. Key words: Infarction, middle cerebral artery; Vinpocetine; Butylphthalide