Effect of vasopressin injection technique on ovarian reserve in patients with ovarian endometriosis cysts excision

Abstract

Objective To investigate the effect of vasopressin injection technique on ovarian reserve in patients with laparoscopic cystectomy of unilateral ovarian endometrioma. Methods 70 patients with unilateral ovarian endometrioma were randomly allocated into study group(37 cases) and control group(33 cases) according to the digital table.Diluted vasopressin was injected into the space between the normal ovarian cortex and the cyst wall before stripping in the study group, and ordinary laparoscopic cystectomy without injection was adopted in control group. The average contents of anti-mullerian hormone(AMH), follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), antral follicle count(AFC) and peak systolic velocity(PSV) were compared in two groups before and after surgery. Results The operative time of the study group was (37.6±8.6)min, which was significantly shorter than (42.8±9.1)min of the control group(t=2.46, P 0.05). The F0 levels in the control group preoperation and postoperation were (8.7±2.8), (4.6±0.7), respectively, there was significant difference between preoperation and postoperation(P 0.05). The AMH levels in the study group preoperation and postoperation were (2.23±0.85)ng/mL, (2.19±0.83)ng/mL, respectively, there was no statistically significant difference between preoperation and postoperation(t=0.20, P>0.05). The FSH levels in the study group preoperation and postoperation were (6.27±2.35)U/L, (6.73±2.23)U/L, respectively, there was no statistically significant difference between preoperation and postoperation(t=0.86, P>0.05). The LH levels in the study group preoperation and postoperation were(5.92±2.32)U/L, (5.57±2.31)U/L, respectively, there was no statistically significantl difference between preoperation and postoperation(t=0.65, P>0.05). The F0 levels in the study group preoperation and postoperation were (9.2±2.4), (8.9±2.7), respectively, there was no statistically significant difference between preoperation and postoperation(P>0.05). The PSV levels in the study group preoperation and postoperation were (14.7±5.4)cm/s, (14.0±4.7)cm/s, respectively, there was no statistically significant difference between preoperation and postoperation(P>0.05). Conclusion Vasopressin injection technique used in unilateral ovarian endometrioma laparoscopic cystectomy is safe and effective, and it can protect the ovarian reserve. Key words: Endometriosis; Ovary; Pituitary hormones, posterior; Laparoscopes; Ovarian function tests