Abstract
This work was started in April, 1929, under the direction of Dr. Ivy on the principle that the active constituent of liver effective in pernicious anemia might be produced by the gastric mucosa and stored in the liver. Very soon after starting our work articles appeared showing that desiccated whole stomach is effective,, that gastric mucosa is slightly effective, whereas gastric muscle is ineffective, that a normal in vivo digest of meat is effective, that pepsin is ineffective, and that gastric juice is ineffective., Our report is simply to record a confirmation of some of these findings. We have fed to pernicious anemia patients fresh hog's gastric mucosa (300 gm. daily) brought to a boil within 20 minutes, pepsin (75 gm. of scale pepsin daily), desiccated mucosa (prepared by the method of Sturgis, Isaacs and Sharp, 75 gm. daily or the equivalent of 450 gm. of fresh mucosa), desiccated gastric muscle (120 gm. daily or the equivalent of 450 gm.) and desiccated whole stomach (120 gm. daily or the equivalent of 450 gm.). It should be pointed out that the preparation of our material (except pepsin) was started within one hour after death of the hog, and that during the process of desiccation there is a considerable opportunity for autolysis to occur which was not the case in the preparation of the fresh hog's mucosa in which the enzymes were destroyed with heat. Three patients did not respond to the fresh hog's mucosa, but did to liver. Two patients did not respond to pepsin, but did to liver. Of 4 patients on desiccated mucosa, one responded definitely but slowly; 3 did not respond, but stated that they felt better, and later responded to liver.
Published Version
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