Effect of various concentrations of Barringtonia racemosa (l). Spreng extract on Physical stability of Topical gel

Abstract

The skin is the largest organ of the human body with various complex functions essential for human survival. The skin protects the body from harmful chemicals, ultraviolet radiation and pathogenic organisms. Wound can be described as a disorders of organs' anatomical structure and function, which includes skin, subcutaneous tissue, muscles, tendons, nerves, blood vessels, and bones. One of the medicinal plants that can be used to accelerate wound healing is Barringtonia racemosa. B. racemosa seeds contain tannins, flavonoids, glycosides, and saponins. To determine the effect of various concentrations of the B. racemosa extract on the physical stability of topical gel. The extract was made into a gel by using carbopol 940 as a thickening agent, methylparaben (nipagin) as a preservative, propylene glycol, triethanolamine (TEA) as a neutralizing agent, and aquadest. In this study, the concentration of B.racemosa seed extract used was 1%, 3%, 5%, and 7% during four weeks of observation. The organoleptic test, homogeneity, pH, and viscosity of the extract were examined. Data were analyzed using the Kruskal Wallis test. The organoleptic test showed that each formula had a distinctive odour, thick consistency, and a significant colour change (p=0.009). All gel preparations are homogeneous. The pH test showed a significant difference in each gel formula's pH (p=0.002). The viscosity test showed that the 7% gel formula was the thickest p=0.001 (<0.05) Various concentrations of B. racemose kernel extracts affect the topical gel's physical stability, including colour, pH, and viscosity.