Abstract
AimTo evaluate the effect of different anti-diabetic treatment strategy on oxidative stress markers in patients with type 2 diabetes mellitus (T2DM).Subject and methodsA total of 93 patients with T2DM treated with metformin (G1 = 25), OHA (G2 = 22), OA and insulin (G3 = 26) and insulin alone (G4 = 20). In all patients, lipid profile and glycemic indices were assessed using routine laboratory tests. MDA and Oxidized LDL were assessed using commercially available ELISA kits. Laboratory tests were performed at baseline and at a control visit after 24 weeks of treatment.ResultsA significant decrease in the levels of MDA with improvement of glycemic control was observed in the group receiving OHA in combination with insulin therapy. A similar decrease of oxLDL was observed in all diabetic subgroups with borderline significance in those receiving metformin alone. The remaining clinical and biochemical parameters were not changed during follow-up in any of the involved groups.ConclusionA combination therapy with insulin was more effective in glycemic control and MDA reduction in T2DM. Whereas, a significant oxLDLc reduction was observed in T2DM irrespective of categories of antidiabetic treatment or glycemic control.
Highlights
Diabetes mellitus (DM) is a major worldwide health problem and considered as one of the leading causes of death and disability [1], with estimated prevalence of more than 500 millions by 2035 [2]
A combination therapy with insulin was more effective in glycemic control and MDA reduction in type 2 diabetes mellitus (T2DM)
A significant oxLDLc reduction was observed in T2DM irrespective of categories of antidiabetic treatment or glycemic control
Summary
Diabetes mellitus (DM) is a major worldwide health problem and considered as one of the leading causes of death and disability [1], with estimated prevalence of more than 500 millions by 2035 [2]. Hyperglycemia, an important pathologic characteristic of type 2 diabetes mellitus (T2DM), measured by percentage of glycated hemoglobin (HbA1c) has long been linked to mortality associated with DM. Chronic hyperglycemia through polyol pathway and protein kinase C increase formation of reactive oxygen species (ROS) inducing a state of oxidative stress that has been proposed as a major pathophysiological link between progression of T2DM and the onset of diabetic complications [3]. ALrefai et al Diabetol Metab Syndr (2017) 9:27 anti-diabetic strategy on oxidative stress markers and their relations with glycemic control, variable clinical and biochemical parameters
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