Abstract
Ultrastructural changes in the mitochondria of intact Ehrlich ascites tumor cells were observed after stimulation by valinomycin of the energy-dependent transport of K + into mitochondria. The mitochondria in cells taken directly from the animal displayed an orthodox configuration. After repeated washings of the cells, the mitochondria were converted to the ‘condensed’ or ‘aggregated’ state. The addition of valinomycin resulted in a transformation of mitochondria from the condensed to orthodox and markedly swollen forms. Alterations in cell size, O 2 uptake, and K + content accompanied the changes in mitochondrial morphology.
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