Abstract
The effect of unilateral lesions of the claustrum was examined in cats treated with d,l-allylglycine. Prior to the lesion, intermittent light stimulation (ILS) induced (a) myoclonic jerking associated with generalized spike, or polyspike and wave discharge, maximal in the subcortical structures monitored and the cortical visual area, and (b) bisymmetrical generalized-onset tonic-clonic convulsions associated with sustained spike discharge in the motor cortex bilaterally. Subsequent to a unilateral lesion of the claustrum, ILS-induced electro-clinical manifestations of myoclonic jerking remained unchanged. However, the bisymmetrical convulsive pattern transformed into a partial onset secondarily generalized convulsive pattern beginning in the intact hemisphere. It is concluded that the claustrum plays an important role for access of visual afferents to the motor mechanism responsible for ILS-induced convulsive seizure.
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