Abstract
Objective To analyze the effect of tumor number on the survival of patients with colorectal liver metastases(CRLM) undergoing hepatic resection and the definition of oligometastases. Methods Clinicopathological data of patients with colorectal liver-only metastases undergoing liver resection from our database were retrospectively analyzed. Results Of all 377 patients, the median number of hepatic tumor was 2. The 5-year disease free survival rate was 24.1%. The 5-year overall survival rate was 39.8%. Survival of oligometastatic patients was not significantly different from non-oligometastatic patients(χ2=3.037, P=0.081). Survival of patients with 6-10 hepatic tumors was similar to patients with 1-5 tumors. However, survival of patients with more than 10 tumors was significantly worse than patients with liver tumor less than 10(χ2=5.386, P=0.020). In multivariate analysis, number of liver tumor, primary node status, largest hepatic tumor and gender are independent predictors of overall survival. Conclusions The number of liver tumor was an independent predictor of overall survival. The cut-off number of oligometastatic disease should be 10. Key words: Colorectal neoplasms; Neoplasm metastases; Prognosis
Published Version
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