Abstract
ABSTRACT Peritoneal macrophages (PM) from normal Wistar rats were treated in vitro with peritonealsupernatant or sera, obtained from rats infected with 10 6 Trypanosoma lewisi trypomastigotes beforethe infection with Toxoplasma gondii tachyzoites. In this experimental model, Toxoplasma multiplication in PM was increased, as compared to macrophages treated with supernatant or serafrom control rats not infected with T. lewisi . This effect was observed only if the active supernatantor sera came from rats infected with the T. lewisi 3 to 6 d before Toxoplasma inoculation.Furthermore, immunosuppressive activity was only detectable after at least 24 h incubation with thesupernatant or sera. These results are in accordance with our in vivo previous studies whichdemonstrated a clear immunosuppressive effect of T. lewisi during T.gondii infection of the remarkablyresistant Wistar rats. Key words : Immunosuppression, Toxoplasma gondii, Trypanosoma lewis i, peritoneal macrophages. INTRODUCTIONImmunosuppressive effects in parasiticinfections allow greater parasite multiplication inthe final host, causing important pathologydevelopment. That is the case of filariosis,schistosomosis, trichinosis and others diseases
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