Abstract
Rats treated with triparanol (MER-29) develop numerous membranous inclusions-“myeloid” bodies in the cytoplasm of liver cells. The “myeloid” bodies did not show cytochemically demonstrable acid phosphatase. Instead diffuse activity was observed throughout the cytoplasm. Biochemically, acid phosphatase was found in the liver lysosomal fraction obtained from triparanol treated rats. This fraction, however, did not show the structure-linked latency of acid phosphatase which is characteristic of normal lysosomes. It is suggested that “myeloid” bodies are lysosomes with altered membranes.
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