Effect of trimetazidine in treatment of ischemic cardiomyopathy heart failure and its influence on cardiac function and heart rate variability

Abstract

Objective To investigate the clinical efficacy of trimetazidine in treatment of ischemic cardiomyopathy heart failure and its influence on cardiac function and heart rate variability. Methods 160 cases of patients with ischemic cardiomyopathy heart failure were randomly divided into the two groups with 80 cases in each group.The two groups were given conventional treatment of anti heart failure,the observation group used trimetazidine on basis of that,clinical effect and the influence on the index of heart rate variability and cardiac function of two groups were observed. Results The total effective rate of the observation group was 91.25%,significantly higher than 73.75% of the control group(χ2= 9.57,P< 0.05);LVEDD and LVESD of the observation group after treatment were(49.88±4.60)mm and(37.10±3.15)mm,significantly reduced than before treatment(t= 7.44,7.83,all P<0.05)and the control group(t= 6.60,6.85,all P< 0.05); while the LVEF was(48.04±4.20)%,increased significantly than before treatment(t= 6.51,P<0.05)and the control group(t= 7.11,P< 0.05); SDNN,SDANN,r MSSD and PNN50 of the observation group after treatment were(124.72±7.02)ms,(111.20±5.89)ms,(46.74±4.22)ms and(17.72±2.08)%,increased significantly than before treatment(t= 7.43,7.83,7.06,8.17,all P<0.05)and the control group(t = 6.66,6.90,6.15,7.21,all P<0.05). Conclusion Trimetazidine has an exact effect in treatment of ischemic cardiomyopathy heart failure,which can improve heart function and heart rate variability which has an important value in clinical application. Key words: Cardiomyopathy,ischemic; Heart failure,congestive; Heart rate variability; Trimetazidine