Abstract
Thyroid hormones have been closely implicated in the pathophysiology of affective disorder. Furthermore, several antidepressant treatments have been shown to decrease thyroid function tests. We evaluated thyroid function tests in 28 subjects with unipolar, nonpsychotic major depression by Research Diagnostic Criteria. As compared with baseline, five weeks of imipramine or desipramine treatment was associated with significant reduction in measures of thyroxine (T4). Furthermore, responders (N = 16) as compared with non-responders (N = 12) had significantly greater decrements in measures of T4. The clinical and theoretical implications of the findings are discussed.
Published Version
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