Abstract
Alterations in thyroid status are frequently associated with changes in mood, especially depression. In particular, therapeutic response to several pharmacological agents used in the treatment of depression has been shown to be associated with decreases in thyroid function tests. Carbamazepine, an anticonvulsant, is effective in the acute and prophylactic treatment of manic depressive illness (Post et al. 1984). It has been recently shown that carbamazepine treatment of primary affective illness is associated with significant reductions in the plasma levels of thyroxine (T4), free T4, and triiodothyronine (T3) without parallel increases in thyrotropin (TSH) (Roy-Byrne et al. 1984). Furthermore, responders to carbamazepine treatment have significantly greater reductions in peripheral thyroid hormone levels than do nonresponders (Roy-Byrne et al. 1984). It has also been shown that depressed patients who respond to lithium treatment have greater impairment of thyroid function than nonresponders (Benaim and Page 1984). Electroconvulsive treatment is also associated with significant reductions in peripheral thyroid hormones as compared with pretreatment levels in responders to treatment (Kirkegaard and Faber 1981). The effects of tricyclic
Published Version
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