Abstract
The purpose of our research was to study the effect of transcranial electrical stimulation on the regeneration of damaged nerve fibers in laboratory animals. In the experiment, an operation was performed to cut the sciatic nerve at the level of the midthigh and to connect its ends with an epiperineural microsurgical suture. After the operation, one group (experimental) of animals was subjected to electrical exposure using electrodes inserted subcutaneously in the forehead and behind the auricles. The electric current was supplied in the mode of a combination of a direct current of 0.8±0.2 mA and a pulse current of 0.4±0.1 mA with a frequency of 70 Hz, a pulse duration of 3.0-3.5 ms. There were 4 sessions of exposure lasting 1 hour with an interval of three days for two weeks after the operation. The animals were monitored for 9 months. Transcranial electroanalgesia (electrostimulation) was found to activate regenerative morpho-functional processes in the nerve fibers of the damaged sciatic nerve in rats.
Highlights
The problem of analgesia affects many theoretical and practical aspects, both in medicine and in veterinary medicine [2,3,4,5,6,7,8,9,10,11,12,13]
The results of the study showed that transcranial electrical exposure has a positive effect on regenerative processes in the peripheral nervous system
In the early stages of regeneration, electroanalgesia stimulates the growth of regenerating nerve fibers, which is manifested in the acceleration of the beginning of foot reinnervation by efferent nerve fibers, on average, by 30%, and by afferent nerve fibers - by 25%
Summary
The problem of analgesia affects many theoretical and practical aspects, both in medicine and in veterinary medicine [2,3,4,5,6,7,8,9,10,11,12,13]. It has been established that electrical stimulation of certain brain structures (hypothalamus, mesencephal, medulla oblongata, etc.) can cause pronounced analgesia in animals by activating the nocic-antinociceptive system [2,3,4,5,6,7,8,9,10,11,12,13] This system is involved in the regulation of pain sensitivity and the conduct of pain impulses in the central nervous system, but is involved in trophic regulation in pathological processes in the body [16]. The purpose of research: to study the effect of transcranial electrical stimulation on the regeneration of damaged nerve fibers in laboratory animals
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