Abstract
The effect of transcranial electrical stimulation at analgesic regimen on regeneration of the rat sciatic nerve after transection and microsurgical suture was studied. Electroanalgesia was found to promote the regenerative outgrowth of the injured nerve fibers, that was manifested in acceleration of foot reinnervation with efferent and afferent nerve fibers by an average of 30 and 25%, respectively. Moreover, electrical stimulation was favorable for the better recovery of the functional properties of the damaged afferents at 9 months after surgery. The involvement of endogenous opioid peptides in regeneration of the peripheral nerves is discussed.
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