Abstract
Intracerebral hemorrhage (ICH) can stimulate neural regeneration, promoting tissue repair and recovery of nerve function. Tongfu Xingshen capsule (TXC) is a Chinese medicinal formula used to treat ICH and has been shown to protect brain tissue and improve nerve function in clinical studies. However, the effect of TXC on endogenous neural stem cells (NSCs) remains elusive. To explore the mechanisms underlying TXC action, a rat model of ICH was established. The effects of TXC on the proliferation and differentiation of NSCs were assessed in the subventricular zone (SVZ). TXC significantly improved nerve function defects, decreased brain water content and restored blood-brain barrier integrity. Additionally, BrdU labeling showed that both high and low doses of TXC significantly increased the proportion of actively cycling NSCs positive for Nestin and glial fibrillary acidic protein, but did not affect the proliferation rates of NeuN-positive neurons. Finally, TXC also upregulated the mRNA levels of brain-derived neurotrophic factor and its receptor, TrκB, in affected brain tissues. Taken together, TXC accelerated neural repair and functional recovery after brain injury by potentially enhancing the proliferation and differentiation of endogenous NSCs into astroglial cells in the SVZ area.
Highlights
Intracerebral hemorrhage (ICH) is a type of stroke associ‐ ated with higher morbidity and mortality rates [1]
ICH injury significantly increased the number of proliferating BrdU‐positive cells in the subventricular zone (SVZ) region, increased by low or high dose Tongfu Xingshen capsules (TXC)‐treated (Fig. 2)
Brain edema following ICH is mainly attributed to the disruption of the blood‐brain barrier (BBB) [32]
Summary
Intracerebral hemorrhage (ICH) is a type of stroke associ‐ ated with higher morbidity and mortality rates [1]. It is a significant cause of death and disability, with an incidence rate of 24.6 per 100,000 person‐years and a fatality rate of 40% in 21 countries between 1980 and 2008 [2]. The poor outcome of ICH is attributed to both direct damages caused by hemorrhage and secondary injuries, such as brain edema, blood‐brain barrier (BBB) disruption, inflammation and neuronal apoptosis [4]. ICH influences brain function, especially cognitive abilities, and may even cause cognitive decline or impairment [5]. Studies have recently focused on the pharmacological treatment of ICH, no effective regimen has been established so far [7]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call