Effect of α-thioctic acid injection combined with deproteinized calf serum on the levels of MCV and SCV in patients with diabetic peripheral neuropathy

Abstract

Objective To investigate the effect of α-thioctic acid injection combined with deproteinized calf serum on motor nerve conduction velocity (MCV), sensory nerve conduction velocity (SCV) and prognosis in patients with diabetic peripheral neuropathy (DPN). Methods 106 cases of DPN patients in our hospital from November 2013 to December 2016 were divided into 2 groups according to the treatment plan, 53 cases in each group. On the basis of conventional treatment, the control group was treated with α-thioctic acid injection, and the observation group was treated with α-thioctic acid injection and deproteinized calf serum. The clinical efficacy and incidence of adverse reactions of the two groups were statistically analyzed. The levels of MCV and SCV of ulnar nerve, median nerve, and peroneal nerve, oxidative stress index [propylene glycol (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px)] before and after treatment were compared. After 3 months of follow-up, the quality of life score was compared between the two groups. Results (1) Nerve conduction velocity: there were no statistically significant differences in the levels of MCV and SCV of ulnar nerve, median nerve, and peroneal nerve between the two groups before treatment (P>0.05). After treatment, the levels of MCV and SCV of ulnar nerve, median nerve, and peroneal nerve of the observation group [(48.56±4.20)m/s, (46.69±4.26)m/s, (44.35±3.97)m/s; (47.52±4.31)m/s, (45.21±4.02)m/s, (46.38±4.36)m/s] were higher than those of the control group, with statistically significant differences (P 0.05]. (4) Oxidative stress: there were no statistically significant differences in the levels of MDA, GSH-Px, and SOD between the two groups before treatment (P>0.05). After treatment, the level of MDA in the observation group [(4.35±1.96) mmol/L] was lower than that in the control group, and the levels of GSH-Px [(141.58±11.22) U/ml] and SOD [(113.17±10.25) U/ml] were higher than those in the control group, with statistically significant differences (P 0.05). After 3 months of treatment, the scores of quality of life in different fields of the observation group [physical function (70.35±9.98) points, psychological function (71.11±9.84) points, social function (72.47±10.95) points, material life status (73.85±11.14) points] were higher than those of the control group, with statistically significant differences (P<0.05). Conclusion α-thioctic acid injection combined with deproteinized calf serum in the treatment of patients with diabetic peripheral neuropathy can effectively improve the nerve conduction velocity and reduce the oxidative stress reaction, with remarkable clinical effect and high safety, which is beneficial to improve the prognosis and the quality of life of the patients. Key words: Diabetic peripheral neuropathy; α-thioctic acid injection; Deproteinized calf serum injection; Nerve conduction velocity