Abstract
This work was carried out to investigate the effect of theobromine exposure on haematological indices in rats and thus evaluate whether its use in chemotherapy may be associated with possible side effects such as anaemia. Theobromine in two doses was administered by oral gavage to albino Wistar rats of both sexes (n =8 for each group) for a four day period. Haematological parameters – indices of blood and erythropoietic status namely packed cell volume (PCV), haemoglobin (Hb), red blood cell count (RBC), white blood cell count (WBC) and mean cell haemoglobin concentration (MCHC) were assessed in whole blood obtained from the animals. The same parameters were assessed in the control group (n =8) administered with only the vehicle. Theobromine administration in moderate (600 mg/Kg body weight) to high (700 mg/Kg body weight) doses produced a significant (P
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