Abstract
The inhibitory effect of urea on human and rabbit muscle M 4-lactate dehydrogenase ( l-lactate:NAD + oxidoreductase, EC 1.1.1.27) is markedly increased in the presence of urease. Evidence is presented suggesting that the action is due to the formation of CO 3 2− which under certain conditions may be shown to be a powerful inhibitor of the M 4 enzyme. NAD + protects the enzyme against both inhibitory systems. The H 4 enzyme, however, is relatively insensitive to both the urea-urease system and to CO 3 2−.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
