Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice.

Hoon Kim,Soon Yeong Park,Dae Kyun Chung

doi:10.3390/ph14030222

Abstract

Most of the studies on common evening primrose (Oenothera biennis L.) are focused on its oils (isolated from seed, root, and stem tissues). We aimed to investigate the effect of the oral administration of OBS-E on the improvement of skin function in skin-damaged hairless mice exposed to excessive ultraviolet B (UVB) radiation owing to the preliminary in vitro findings regarding the antioxidant, anti-wrinkle, and skin moisturizing activities of OBS-E. OBS-E administration for 14 weeks did not significantly affect the body weight or clinical signs. Significant reductions were observed in wrinkle parameters (area, number, length, and depth, and metalloproteinase levels) in OBS-E-administered mice compared with those in UVB-irradiated control mice. OBS-E significantly increased skin elasticity and hyaluronic acid content, but it significantly decreased transepidermal water loss. Histomorphometrical analysis revealed that OBS-E significantly reduced the epidermal thickness, area of the collagen-occupied region, and number of microfolds and inflammatory and mast cells. These results demonstrate that OBS-E can effectively enhance skin functions in terms of ameliorating wrinkle formation, promoting skin-moisturization, enhancing skin barrier function, and inhibiting inflammatory reactions. The obtained results provide good starting point for the continuation in the process of developing new inner beauty products based on OBS-E.

Highlights

In recent decades, there has been an increased interest in delaying aging in the scientific and industrial fields
As it is well known that consistent ultraviolet B (UVB) exposure induces the expression of Matrix Metalloproteinase (MMP) followed by the inhibition of procollagen synthesis, resulting in the degradation of the collagen matrix of the skin [21,22], our results indicate that orally administered O. bienniscontaining (OBS)-E reduces wrinkle formation in the skin tissue damaged by photoaging and that the activity may be caused by downregulation of MMP-2 and MMP-9
The effect of the oral administration of OBS-E on skin function improvement was investigated in a UVB-irradiated hairless mouse model

Summary

Introduction

There has been an increased interest in delaying aging in the scientific and industrial fields. Numerous plants and their extracts have been recognized as major sources for preventing skin aging in humans [2]. Evening primrose, belonging to the genus Oenothera, is a biennial herbaceous plant with yellow flowers [5]. Various physiological and medicinal properties of O. biennis have been reported, including antioxidant [7,8,9], anti-inflammatory [10,11], anti-cancer [12], Pharmaceuticals 2021, 14, 222. The most familiar and widely studied species of the Oenothera family is Oenothera biennis L., known as the common evening primrose.

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