Abstract
OVULATION can be stimulated in isolated segments of frog ovary by the addition of hormones1,2 but is prevented by actinomycin D3; this has led to the suggestion that ovulation is contingent on the synthesis of RNA3,4. Indeed, actinomycin D is known to inhibit RNA synthesis in ovaries as well as ovulation4, while hormonal stimulation is followed by increased uridine incorporation into the cells of the peritoneal surface of the ovary5, through which ovulation occurs.
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