Effect of the Immunoglobulin G-A-M Treatment on Hepatic Functions and Mortality rates in Patients with Septic Shock

Abstract

Introduction and aim: In this study, we aimed to explore the effects of conventional sepsis treatment, including classical antibiotherapy and IgG-A-M combinations, on liver function tests in patients with severe sepsis. Methods: All patients diagnosed with severe sepsis and treated with IgG- A- M combinations in the Adult Intensive Care Unit of Suleyman Demirel University Practice and Research Hospital between 2005-2013 were retrospectively examined. Demographic properties, age, gender, intensive care treatment duration, general exitus day, the death rate in the first 28 days, rate of the general death-survival period, 28th-day death rate, general death rate, diagnoses of cases were recorded. Results: AST- ALT- Albumin values of cases before and after Ig G- A- M combination treatments were also recorded. In statistical comparisons, p< 0,05 was assumed to be significant. In this study, it was observed that IgG- A- M combination (Pentaglobin®) treatment had no statistically significant impact on AST- ALT- Albumin values. Conclusion: Sepsis is a clinical condition that continues to have a high mortality rate despite advances in treatment modalities. Although anti-infective And anti-inflammatory treatments are used, there is no clear data on their efficacy.However, early diagnosis of sepsis, early initiation of antibiothearpy, early source control and timely initiation of appropriate fluid therapy play a key role in succsess of sepsis treatment. For this purpose, as emphasized in the sepsis 3 guideline, we think that raising awareness by physicians and practitioners in early diagnosis of sepsis is the Most important step in the treatment of this clinical condition.