Research progress on biomarkers for early diagnosis of sepsis

Abstract

Sepsis is a complex systemic inflammatory response syndrome caused by infection.Sepsis can deteriorate to severe sepsis, septic shock, and multiple organ dysfunction syndrome.Due to the use of antimicrobial agents, fluid resuscitation and the developments of all kinds of support life, the treatment of sepsis has greatly improved over the past years.However, the mortality rates of sepsis still remain high.Rapid, accurate and early diagnosis of sepsis is a key factor to lower the high mortality rate of sepsis.Recently, it has been found that some biomarkers are closely associated with early diagnosis of sepsis and are helpful for the treatment.These biomarkers for early diagnosis include presepsin(sCDl4-subtype), neutrophil CD64, soluble triggering receptor expressed on myeloid cells-1(sTREM-1), soluble CD163, microRNAs, copeptin, and so on.Examining these biomarkers alone or in combination will bring new opportunities for the early diagnosis of sepsis, and hopefully provide new ideas for the treatment of sepsis.This article reviews the progress on the current emerging biomarkers for early diagnosis of sepsis. Key words: Sepsis; Early diagnosis; Biomaker