Abstract
The human papillomavirus (HPV) is an etiological factor and a biological carcinogen in tumor lesions and cancer. Currently, many possible mechanisms of immune evasion of are known. There is still a need to expand early methods for diagnosing papillomavirus infection and finding effective treatments. The results of a study of the spontaneous and induced amount of cytokines produced by dendritic cells in vitro in response to stimulation with the synthesized L2 peptide of the human papillomavirus type 16 are presented.It was found that the interaction of human blood-derived dendritic cells with the minor capsid peptide L2 of HPV type 16 disrupts the synthesis of pro-inflammatory and anti-inflammatory cytokines, which leads to an imbalance in the immune response, and may indicate an effective mechanism for HPV evasion from the inflammatory response and the formation of an immunodeficiency state.
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