Abstract
The effects of various doses of aqueous extract of the leaves and seeds of Persea Americana, a widely used medicinal plant, on the enzyme activities of some rat tissues were studied. The effect of these extracts on cholesterol as a metabolite was also investigated. The enzymes assayed were Alkaline Phosphatase (ALP), acid phosphate (ACP), Alanine Aminotransaminase(ALT), and Aminoaspartate Transaminase (AST). The results obtained showed that there was a significant decrease (P<0.05), in the activities of all enzymes studied in the liver of the rat. There was a concomitant increase in the activities of these enzymes in the plasma possibly due to leakages into the blood. This result indicates a probable damage to the hepatic cells which may be as a result of prolonged usage of the aqueous extract of the leaves and seeds of Persea Americana. Also, there was a significant decrease (P<0.05) in the cholesterol level in the plasma and liver of rats. The result obtained indicates Persea Americana to have hypocholesteric effect, thereby suggesting it may help in the treatment of
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