Abstract
The antidepressant agent, Stelazine (trifluoroperazine dihydrochloride), is known to cause inactivation of the calcium-binding protein, calmodulin. We report here that this drug in the concentration range of 5 × 10 −5M to 10 −6M causes remarkable inhibitory effects on ligand-induced T-lymphocyte receptor capping. The possible involvement of calmodulin in the regulation of lymphocyte surface receptor movement is therefore implicated.
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