Abstract
Six outpatients suffering from atopic dermatitis underwent the α-linolenic acid enriched diet, that is, reducing n-6 series polyunsaturated fatty acid (linoleic acid, arachidonic acid [AA]) intake and increasing n-3 series polyunsaturated fatty acid (α-linolenic acid, eicosapentaenoic acid [EPA]) intake using perilla oil to suppress the release of chemical mediator derived from arachidonic acid cascade. After 124±40.4 (mean±SD) days of this treatment, improvement of the dermatitis was observed in three patients, and in another one patient by continuing the diet after this study. In the phospholipid fraction in their serum, the n-3/n-6 ratio and the EPA/AA ratio were significantly increased (p<0.01). According to that, Leukotriene C4 release from polymorphonuclear leukocytes by zymosan and fresh autologous serum was significantly decreased (p<0.05). This results suggest that daily meals consist in the α-linolenic acid enriched diet have some benefit in the treatment of allergic diseases.
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Schedule a callMore From: Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
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