Abstract
Sulfanilic acid or sulfaguanidine was injected as a marker drug intravenously into the rat, the small intestine was perfused with either tetracycline solution or isotonic buffer solution, and the amount of injected drugs exsorbed to the perfused solution was examined. This procedure excludes any interaction between tetracycline and the marker drugs and is sensitive enough to detect any permeability change caused by the former drug. It was found that the exsorption of marker drugs increased to a considerable extent in the case of tetracycline at pH 8.0, which agreed with the result of a previous experiment on enhancement of intestinal absorption of sulfa drugs in the presence of tetracycline. This effect of tetracycline is attributable to its influence on the small intestinal tissue.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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