Abstract
The protein anabolic effect of testosterone has been observed in many situations (Kochakian, 1950; Kenyon et al., 1944). Kochakian (1950) reported that administration of testosterone propionate to castrated and normal male rats resulted in a reduced urinary nitrogen excretion which could be correlated with protein deposition in kidney, liver, and carcass as well as in accessory sexual tissue. Kochakian (1950) and Gordon et al. (1947) observed that testosterone administration reduced urinary nitrogen excretion also in hypophysectomized rats, suggesting that the protein anabolic effect of testosterone was not mediated through the pituitary gland. The site of protein retention was not determined in these studies. Simpson et al. (1944) found that testosterone administration had no significant effect on body length and weight gains of hypophysectomized rats unless given jointly with anterior pituitary growth hormone. Atrophy of the temporal muscle was observed following gonadectomy in the male guinea pig by Pa...
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