Abstract
Multidrug resistance and various adverse side effects have long been major problems in cancer chemotherapy. Recently, chemotherapy has gradually transitioned from mono-substance therapy to multidrug therapy. As a result, the drug cocktail strategy has gained more recognition and wider use. It is believed that properly-formulated drug combinations have greater therapeutic efficacy than single drugs. Tea is a popular beverage consumed by cancer patients and the general public for its perceived health benefits. The major bioactive molecules in green tea are catechins, a class of flavanols. The combination of green tea extract or green tea catechins and anticancer compounds has been paid more attention in cancer treatment. Previous studies demonstrated that the combination of chemotherapeutic drugs and green tea extract or tea polyphenols could synergistically enhance treatment efficacy and reduce the adverse side effects of anticancer drugs in cancer patients. In this review, we summarize the experimental evidence regarding the effects of green tea-derived polyphenols in conjunction with chemotherapeutic drugs on anti-tumor activity, toxicology, and pharmacokinetics. We believe that the combination of multidrug cancer treatment with green tea catechins may improve treatment efficacy and diminish negative side effects.
Highlights
Tea made from the plant species Camellia sinensis is the most widely consumed beverage other than water
This study showed that epigallocatechin gallate (EGCG) + ibuprofen treatment resulted in greater growth inhibition than ibuprofen or EGCG alone
When the animals were pretreated with EGCG, the CPT-11 and SN-38 area under the plasma concentration-time curves (AUC) in plasma were increased by 57.7% and 18.3%, respectively, while the AUC
Summary
Tea made from the plant species Camellia sinensis is the most widely consumed beverage other than water. Combination chemotherapy is an approach to canceroftreatment that utilizes multiple medications This approach can overcome the disadvantages monotherapy and enhance therapeutic effects in cancer treatment [11]. Due to their various health benefits, green tea medications. This approach can overcome the disadvantages of monotherapy and enhance therapeutic polyphenols increasingly prevention or benefits, as an adjuvant in chemotherapy Duefor to cancer their various health green tea polyphenols are Previous studies havecancer demonstrated that combining chemotherapeutic drugs with green tea could increasingly used for prevention or as an adjuvant in chemotherapy. We believe that the combination of green tea catechins and anticancer drugs may enhance cancer treatment efficacy and diminish negative effects. We believe that the combination of green tea catechins and anticancer drugs may enhance cancer treatment efficacy and diminish negative effects. and Chemotherapeutic Agents
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