Abstract
The aim of the present work was to study the effects of taxifolin, a conjugate of taxifolin with glyoxylic acid, and naringenin on phagocytosis of latex beads by neutrophils and adhesive properties of these cells. It was shown that taxifolin had no effect on the phagocytic activity and adhesive properties of neutrophils. A conjugate of taxifolin with glyoxylic acid strongly inhibited the phagocytic activity of neutrophils. At the same time, the conjugate significantly enhanced adhesion of these cells. Naringenin decreased phagocytic activity of neutrophils, though to a lesser extent than the conjugate did. Naringenin also inhibited adhesion of neutrophils. Thus, the data collected during our study indicate that polyphenols may influence the functional activity of neutrophils that can play an important role in the modulation of inflammation, especially when prolonged activation of neutrophils leads to tissue damage.
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