Effect of tanshinone IIA sodium injection on gastrointestinal surgical incision healing

Abstract

Objective To analyze and discuss tanshinone Ⅱ A sodium injection in the clinical results of gastrointestinal surgery wound healing, so as to provide the evidence for clinical treatment. Methods One hundred and twenty cases of gastrointestinal surgery were selected from January 2014 to June 2015. They were randomly divided into observation group and control group using random number table method, with 60 cases in each group. The control group received routine treatment with antibiotics and other symptomatic drugs, and the observation group received additional tanshinone Ⅱ A sodium injection. The wound healing time, incidence of adverse events, pre- and post-operative 1, 3, 5 d level of C-reactive protein (CRP) and whole blood viscosity level between the two groups were compared. Results The average healing time of the observation group was (7.06±0.71) d, and (9.27±0.82) d in the control group; the healing time of the observation group was significantly shorter than that of the control group (t=15.782, P<0.01). In the control group, the infection rate of incision and incisional liquefaction rate were 10.00% (6/60) and 13.33% (8/60) respectively, significantly higher than those of the control group (0% and 1.67%, χ2=6.316, 5.886, P=0.012, 0.015). There was no significant difference in CRP and whole blood viscosity indexes between the two groups before and after operation, and the recovery time of observation group was more quickly (P<0.05). Conclusion Tanshinone Ⅱ A sodium injection for parenteral surgical incision healing has certain benefit in controlling the incision fat liquefaction, and can speed up incisional healing time. Key words: Digestive system surgical procedures; Wound healing; C-reactive protein; Tanshinone ⅡA sodium