Abstract
Background: Tamoxifen is selective estrogen receptor modulators, used in treatment of breast cancer, some literatures reported its impact on the process of peroxidation. Aim: The aim of this study was to evaluate the effect of tamoxifen on ethanol induced gastric ulcer in rats. Method: Gastric ulcers were induced in Wistar albino rats by oral administration of absolute alcohol (1 ml/200 g). Antiulcer activity of tamoxifen (0.5 and 10 mg/kg, p.o.) was observed and compared to standard drug (omeprazole 20mg/kg, p.o.), the ulcer index, ulcers numbers, lengths, gastric volume and total gastric acidity were evaluated. Histopathology is performed for confirmation. Results: Tamoxifen in 10mg/kg dose produced a highly significant (P<0.001) decrease in ulcer parameters studied compared to ulcer control. While 0.5 mg/kg of tamoxifen produced a less significant (P<0.01) effect on gastric volume when compared to the ulcer group. The anti-ulcer effects of the drug of interest is highly compared to omeprazole was very, surprisingly; the higher dose of tamoxifen produced even a much significant reduction in gastric volume and ulcers length compered to standard drug. Conclusion: Tamoxifen shows significant antiulcer activity against ethanol induced gastric ulcers, and this could possibly related to its antioxidant properties.
Highlights
Tamoxifen (TAM) is one of the most commonly gastric mucus, and nitric oxide
The rats given 20mg/kg of omeprazole showed significant improvement (P
The present study showed significant reduction in number and size of gastric lesions, and in ulcer index (UI) in the groups treated with TAM at both low and high doses compared to ulcer control
Summary
Tamoxifen (TAM) is one of the most commonly gastric mucus, and nitric oxide. In addition to reduction in used exogenous hormonal therapy intended for treatment of gastric blood flow and induction of oxidative stress [7].breast cancer estrogen receptor (ER)-positiveBased on the previously mentioned properties of breast cancer [1]. Some Available literatures reported that TAM could interfere with peroxidation process in animal and human systems both in-vivo and in-vitro [3,4,5] This hypothesis leads us to suggest that TAM might improve ethanol induced gastric ulcer, which considered a very common animal model to study ulcer experimentally [6]. Tamoxifen is selective estrogen receptor modulators, used in treatment of breast cancer; some literatures reported its impact on the process of peroxidation. Aim: This study was aimed to evaluate the effect of tamoxifen on ethanol induced gastric ulcer in rats. The anti-ulcer effects of the drug of interest is highly comparable to omeprazole was very, surprisingly; the higher dose of tamoxifen produced even a much significant reduction in gastric volume and ulcers length compared to standard drug.
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