Effect of systemic long-term, low-dose aspirin on periodontal status and soluble CD14 in gingival crevicular fluid: a case-control study.

Abstract

In the present study, we evaluated the effect of systemic long-term, low-dose aspirin on the periodontal status and gingival crevicular fluid (GCF) concentrations of aspirin-triggered lipoxins (ATL) and soluble CD14 (sCD14). The study group consisted of 45 patients who were on long-term, low-dose aspirin therapy, and the control group included patients not on aspirin therapy. Mean bleeding index, plaque index (PI), probing depth (PD), and clinical attachment loss (CAL) were recorded. GCF samples were analyzed for concentrations of ATL, and sCD14 using enzyme-linked immunosorbent assay method. The means of PI, PD, and CAL were higher for the control group compared to the study group. The mean concentration of ATL was significantly higher for the study group (49.13±37.39ng/mL). The mean concentration of sCD14 was higher in the control group (5.75±3.91μg/mL). There was a negative correlation in the study group between concentrations of ATL with PD (r=-0.54) and CAL (r=-0.123). There was a positive correlation between sCD14 and CAL (r=0.047) in the study group. A negative correlation was also observed between concentrations of sCD14 and ATL (r=-0.134) in the study group. The results indicate better periodontal status among long-term aspirin users compared to non-aspirin users.