Abstract
Serum gonadotropins (LH and FSH) have been assayed in 24 agonadal patients (10 children up to 11 yr and 14 adolescents aged 12 to 19 yr). The effects of synthetic luteinizing hormonereleasing hormone (LH-RH) on serum LH and FSH have been evaluated in 14 of them. In all agonadal patients aged 12 yr or more, serum LH and FSH and response to LH-RH were increased to very high levels. In agonadal children up to 11 yr, mean serum gonadotropins and response to LH-RH were significantly less increased, with large individual variations, and an apparent decline in the 10–11-yr age group. These facts demonstrate that the change of the hypothalamo-pituitary gonadotropic regulation which occurs at the beginning of adolescence can not be related to the effect of gonadal steroids. It may be questioned if nongonadal steroids and/or other factor(s) influence the adolescent change of gonadotropic control.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: The Journal of clinical endocrinology and metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.