Responses of serum luteinizing hormone and follicle-stimulating hormone levels to synthetic luteinizing hormone-releasing hormone (LH-RH) in various forms of testicular disorders.

Abstract

ABSTRACT Synthetic luteinizing hormonereleasing hormone (LH-RH) was administered to normal men and to patients with oligospermia, azoospermia and hypergonadotropic and hypogonadotropic eunuchoidism. Intramuscular injection of 100 μg of LH-RH provoked significant increases in both serum LH and FSH levels in 30 min. The magnitude of responses in serum LH and FSH levels was largely dependent on basal levels, i.e., larger increments were observed in cases with higher basal levels. Responses of serum LH levels in cases with hypogonadotropic eunuchoidism were below the normal range, while those of serum FSH levels showed a considerable overlap into the normal range of responses. There were no responses of LH or FSH levels to LH-RH in cases of hypogonadotropic eunuchoidism under the treatment with testosterone or in cases of prostatic cancer under estrogen treatment.