Abstract
ABSTRACT Following the acute intravenous injection of synthetic luteinizing hormone-releasing factor (LRF), plasma testosterone rises to peak levels by 4 hr and increases significantly (p = .02) in adult and pubertal males but not in prepubertal males. The mean maximal increase above basal testosterone levels ±sem in ng/100 ml was 132 ± 31 in 10 adult males, 52 ± 13 in 18 pubertal males, and 0.9 ± 2 in 8 prepubertal males. There was a positive correlation (p pubertal males > prepubertal males. We conclude that an ordered, sequential maturation of the hypothalamic → pituitary gonadotropin → gonadal axis presages the onset of puberty in man.
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