Effect of synthetic chicken and porcine vasoactive intestinal peptide on pancreatic blood flow in dogs

Abstract

Studies were conducted in dogs to determine the effect of synthetic chicken and porcine vasoactive intestinal peptide on blood flow and exocrine secretion of the pancreas and on systemic arterial pressure. The stimulatory effect of synthetic chicken vasoactive intestinal peptide on blood flow and exocrine secretion of the pancreas was almost similar to that observed after synthetic porcine vasoactive intestinal peptide stimulation, whereas, synthetic chicken vasoactive intestinal peptide retained only approximately two thirds of the potency of synthetic porcine vasoactive intestinal peptide in its effect on lowering systemic arterial pressure. This study suggests that an increase in exocrine pancreatic secretion may be related to an increase in pancreatic blood flow in response to vasoactive intestinal peptide. This study leads us to speculate that total amounts of splanchnic organ blood flow increased in response to porcine vasoactive intestinal peptide are much more greater than those after chicken vasoactive intestinal peptide stimulation, although we cannot exclude the possibility that porcine vasoactive intestinal peptide may be much more potent in its effect on vasodilatations in peripheral systemic vessels in comparison with chicken vasoactive intestinal peptide.