Abstract
Sympathetic denervation of submaxillary glands of rats by means of superior cervical ganglionectomy resulted in significant increases of the 5-hydroxytryptamine concentration and total 5-hydroxytryptamine content. Sympathetic denervation reduced significantly the weight of the glands but this decrease was less marked than the previously observed reduction in gland weight following immunosympathectomy. These observations indicated that absence of sympathetic innervation may be responsible for the previously observed increase of the 5-hydroxytryptamine levels in a number of peripheral tissues of rats following immunosympathectomy.
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