Abstract
The effect of sympathetic denervation on nerve growth factor (NGF) immunoreactivity in the submandibular and parotid glands of adult female rats using a two-site, enzyme-linked immunosorbent assay was investigated. Unilateral sympathetic denervation through the avulsion of the superior cervical ganglion resulted in elevated levels of total amounts (decreased from 40–20%) and concentrations (decreased from 45–32%) of NGF in the submandibular glands, but not in the parotid glands, on the operated side 7–28 days post-operatively. Sympathetic decentralisation had no effect. The present findings support the hypothesis that increased levels of NGF play an important part in the increased activity of the acetylcholine-synthesising enzyme, choline acetyltransferase, in the rat submandibular gland following sympathetic denervation.
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