Abstract
The aim of the study was to evaluate the impact of cholecalciferol supplementation on blood pressure (BP) in patients with arterial hypertension (AH) in the area of Blida (Algeria). A prospective, cohort, single-center study of 898 individuals with AH (54.1 ± 5.8 years) was performed. In addition to antihypertensive therapy every patient was recommended to take cholecalciferol 2000 IU/month. The duration of cholecalciferol supplementation was 3.5 ± 1.7 months. The duration of follow-up was 12.4 ± 1.2 months. The “dynamics” (d) index was calculated as a difference between values before and after administered therapy. At baseline office systolic (SBP) and diastolic BP (DBP) averaged at 164/91 mmHg. On the follow-up there were their significant ( P < 0.001) reduction and were 131/82 mmHg correspondingly. Target levels of office BP measurements were achieved in 78.1% for SBP and 89.5% for DBP. Serum 25(OH)D total at baseline was 12.4 ng/mL, at the end of the follow-up period was 48.4 ng/mL ( P < 0,01). Correlation relationship between dSBP and duration of cholecalciferol intake was established ( R = 0.47; P = 0.02). It was found that intake of diuretics (hydrochlorothiazide at a dose of 12.5 mg and higher) as part of combination of antihypertensive therapy influenced the dynamics of serum 25(OH)D (F = 4.4; P = 0.01) and its level ( F = 10.9; P = 0.01). The highest d25(OH)D was found in the group of patients without diuretics intake. dSBP value was highest (–31.5 ± 19.5) in the group receiving diuretics and cholecalciferol, which was significantly ( P < 0.001) different from the comparison group. No difference was found for the total amount of antihypertensive medication that was used at 6 and 12 months. The combined use of cholecalciferol at a dose of 2000 IU/month and diuretic therapy of patients with arterial hypertension allowed to obtain the greatest hypotensive effect on blood pressure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.