Abstract
AbstractNumerous effects on metabolism of Lipids, its absorption, amalgamation, and control is under the influence of Thyroid Hormone. The scientists at international are exploring the possibility of establishing a link between subclinical hypothyroidism and lipids. We conducted this research to test the hypothesis that TSH, and levels of LDL-C and HDL-C are significantly associated in subjects with SCH.Methods: This cross sectional study was conducted at Physiology Department, KEMU in collaboration with Centre for Nuclear Medicine (CENUM), Mayo Hospital & KEMU, Lahore. Simple Random sampling technique was employed to collect the sample. A total of 100 cases were selected (50 with SCH and 50 with Thyroid Profile within normal range as control) Levels of TSH, LDL-C and HDL-C were measured in fasting serum samples.Results: TSH levels in subclinical hypothyroidism SCH were 8.69 mlU/L and Euthyroid showed to be1.39 mlU/L. Mean HDL levels were 39.74 mg/dL in Subclinical Hypothyroidism subjects and 43.48mg/dL in euthyroid. The LDL-C pattern was in SCH 182.82 mg/dL and Euthyroids 161.24 mg/dL.Conclusion: The Subclinical hypothyroidism has statistically significant effect in lowering HDL-C and increasing LDL-C level.AbstractNumerous effects on metabolism of Lipids, its absorption, amalgamation, and control is under the influence of Thyroid Hormone. The scientists at international are exploring the possibility of establishing a link between subclinical hypothyroidism and lipids. We conducted this research to test the hypothesis that TSH, and levels of LDL-C and HDL-C are significantly associated in subjects with SCH.Methods: This cross sectional study was conducted at Physiology Department, KEMU in collaboration with Centre for Nuclear Medicine (CENUM), Mayo Hospital & KEMU, Lahore. Simple Random sampling technique was employed to collect the sample. A total of 100 cases were selected (50 with SCH and 50 with Thyroid Profile within normal range as control) Levels of TSH, LDL-C and HDL-C were measured in fasting serum samples.Results: TSH levels in subclinical hypothyroidism SCH were 8.69 mlU/L and Euthyroid showed to be1.39 mlU/L. Mean HDL levels were 39.74 mg/dL in Subclinical Hypothyroidism subjects and 43.48mg/dL in euthyroid. The LDL-C pattern was in SCH 182.82 mg/dL and Euthyroids 161.24 mg/dL.Conclusion: The Subclinical hypothyroidism has statistically significant effect in lowering HDL-C and increasing LDL-C levels.Key words: Subclinical hypothyroidism, TSH, HDL-C, LDL-C
Highlights
The endocrinologists have recently focused their attention on the possibilities of an underactive thyroid gland undetectable by lack of its symptoms.[1]
Normal free T3 was taken in a range of 2.5 to 5.8 pmol/L, Free T4 in a range of 11.5 to 23.0 pmol/L and Thyroid stimulating hormone (TSH) was taken in a range of 0.20 to 4.00 mlU/L
50 cases of subclinical hypothyroid were taken, in which the TSH mean level has come out to be 8.69 with standard deviation (SD) of 3.83 and standard error of mean (SEM) is .54, which is reasonably high as compared to the upper normal limit for TSH which is 4
Summary
The endocrinologists have recently focused their attention on the possibilities of an underactive thyroid gland undetectable by lack of its symptoms.[1]. Numerous effects on metabolism of Lipids, its absorption, amalgamation, and control are under the influence of Thyroid Hormone. Current studies reveal that if the levels of Thyroid Hormone are explicitly low, the levels of Cholesterol, LDL-C and Triglyceride rise.[3]. Thyroid disorders hypothyroidism tends to effect the blood pressure of the individual (diastolic) and if it is added up with raised levels of lipids i.e. Triglyceride, & Cholesterol it would help formation of atheromatous plaques in the arteries and case of cardiovascular system they can be dangerous and life threatening. Hypothyroidism raises the levels of the lipids, which are a major contributing factor to heart disease.
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