Abstract
Introduction. Strontium salts are anti-irritants for chemically induced sensory irritation. Interstitial cystitis is a painful disease without definitive therapy. The aim of the study was to determine the effect of strontium in bladder with experimental interstitial cystitis model. Material and Methods. Rats' bladders in control group were instilled with NaCl. Second group was instilled with E. coli LPS. Third group was instilled with strontium. Fourth group was initially instilled with strontium and then LPS. Fifth group was instilled with LPS initially and then strontium. Urine of rats was collected at the beginning and end of the study. Results. Histamine and TNF-α changes were statistically significant in the second group but were not significant in the third group. When we compared the histamine levels of second via fourth and fifth groups the changes were statistically not significant. When we compared the TNF-α levels of second via fourth and fifth groups the changes were statistically significant. Conclusions. In our model, strontium did not make any significant changes in histopathology or histamine levels; however, it significantly reduced the levels of TNF-α. Given the role of TNF-α in the physiopathology of interstitial cystitis, these results suggested that further studies are required to evaluate the potential use of strontium in the management of interstitial cystitis.
Highlights
Strontium salts are anti-irritants for chemically induced sensory irritation
The role of TNF-α in the development of the IC has been revealed in various studies [5, 6]. One of these studies showed that apoptosis of urothelial cells in patients with Interstitial cystitis/painful bladder syndrome (IC/PBS) could result from upregulation of inflammatory signals, including TNF-α [5]
Another study demonstrated that TNF-α induces apoptosis via TNF-related apoptosis inducing ligand (TRAIL) and its receptors in IC/PBS patient’s bladder tissue samples [6]
Summary
Strontium salts are anti-irritants for chemically induced sensory irritation. Interstitial cystitis is a painful disease without definitive therapy. Interstitial cystitis/painful bladder syndrome (IC/PBS) was defined by the Society for Urodynamics and Female Urology as “an unpleasant sensation (pain, pressure, and discomfort) perceived to be related to the urinary bladder, associated with the lower urinary tract symptoms for more than 6 weeks duration, in the absence of infection or other identifiable causes” [1]. It is a common problem and affects 2.7%–6.5% of all women [2]. Another study demonstrated that TNF-α induces apoptosis via TNF-related apoptosis inducing ligand (TRAIL) and its receptors in IC/PBS patient’s bladder tissue samples [6]
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