Effect of stem cells transplantation on decompensated hepatic cirrhosis: a Meta-analysis

Abstract

Objective To evaluate the effect of stem cells transplantation on liver function in patients with decompensated liver cirrhosis.Methods Randomized controlled trials (RCTs) about effect of stem cells transplantation on liver function in patients with decompensated liver cirrhosis were retrieved from CNKI,Wanfang database,CBMdisc,CALLS thesis database,Pubmed,Embase,Cochrane Library and Google academic online database and screened.Quality evaluation and Meta-analysis of included literatures were conducted.Results A total of 29 RCTs involving 1 161 patients were collected.Meta-analysis results showed that the baselines of main observational index in treatment group and control group were undifferentiated.However,4,8,12 weeks after transplantation,the levels of alanine aminotransferase (ALT) [MD4weeks=-17.17,95％CI (-24.90,-9.43),P＜0.001],[MD8weeks=-14.80,95％CI (-22.32,-7.28),P＜0.001],[MD12weeks=-15.5,95％CI(-28.47,-2.52),P＜0.001] and total bilirubin (T-Bil) [MD4weeks=-5.92,95％CI (-9.72,-2.13),P＜0.001],[MD8weeks=-12.02,95％CI(-18.78,-5.25),P＜0.001],[MD12weeks=-1 1.23,95％CI (-19.61,-2.84),P＜0.001] in treatment group were significantly lower than that in control group.And the levels of albumin (ALB) [MD4weeks=2.87,95％CI (1.83,3.92),P＜0.001],[MD8weeks=5.11,95％CI (3.90,6.31),P＜0.001],[MD12weeks=4.66,95％CI (2.10,7.22),P＜0.001] and prothmmbin activity (PTA) [MD4works=3.76,95％CI (-0.98,8.49),P＜0.001],[MD8w=7.92,95％CI (4.25,11.58),P＜0.001],[MD12weeks=10.51,95％CI (-2.15,23.17),P＜0.001] in treatment group were significantly higher than control.Conclusions Liver function in patients with decompensated liver cirrhosis can be significantly improved by transplantation of stem cells,and more registered clinical trials are necessary for the potential development of stem cells treatment technology. Key words: Stem cells; Transplantation; Liver cirrhosis; Liver failure; Meta-analysis