Abstract
SummaryA single injection of statolon administered prior to aerogenic immunization with mengovirus-37A resulted in reduced amounts of virus in lungs, spleen, and blood of treated mice and a decrease in resistance to lethal aerosol doses of the antigenically similar Columbia-SK virus. There was a delay as well as diminution in antibody response which, along with decreased virus titers, could be associated with serum interferon levels. Mice treated with statolon prior to aerogenic immunization and later subjected to lethal aerosol challenge exhibited resistance which was not consistent with humoral antibody levels.
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