Effect of Spiramycin and Moringa leaf feeding in improving placenta, heart, histopathological neurons and glia in fetal models with toxoplasmosis

Abstract

Background: Toxoplasmosis is a protozoan disease caused by Toxoplasma gondii that can cause fetal abortion, stillbirth, death, or fetal and neonatal abnormalities. Spiramycin prophylactic purpose is to prevent fetal infection in toxoplasmosis. While Moringa oleifera contains bioactive compounds that benefit from treating oxidative stress and infections. This study aims to evaluate the effect of Spiramycin and Moringa leaf extract in improving the placenta, heart, histopathological neurons and glia in fetal rat models with toxoplasmosis. Methods: An experimental study with a post-test-only control group design was done using 24 pregnant female rats divided into the control group receiving spiramycin therapy (P1) and two intervention groups that were given spiramycin and ethanol extract from Moringa leaves at a dose of 240 mg/kg body weight (P2) and combination of spiramycin and ethanol extract from moringa leaves at a dose of 420 mg/kgBW (P3). A histopathological examination was then performed. Results: Administration of spiramycin and ethanol extract of Moringa leaves at 420 mg/kg body weight had the same histopathological examination results as spiramycin administration. In a histopathological examination of toxoplasmosis pregnant rat placenta and toxoplasmosis fetal rat heart was effective in repairing gliosis in neurons and neuroglia of toxoplasmosis rat fetuses. Conclusion: Administration of spiramycin and ethanol extract from Moringa leaves was effective in repairing gliosis in neurons and neuroglia of toxoplasmosis rat fetuses.