Abstract
Purpose: To evaluate the wound-healing effect of Spatholobus suberectus (Fabaceae) on seconddegree burns in a rat model.Methods: The animals were divided into normal, negative control, as well as 10 % Spatholobus suberectus (SS) (SS10), 20 % SS (SS20) and standard (STD) groups. Second-degree burns were inflicted by exposing a 3 × 3 cm sterile area of skin to boiling water for 10 min. The animals were treated topically twice daily for 2 weeks. Wound contraction (%) was measured after 2 weeks, while wound tissue histopathology was assessed by hematoxylin & eosin and Masson’s trichrome staining. In addition, lipid peroxidation (malondialdehyde kit) and cytokine secretion (ELISA) were measured in liver and plasma, respectively.Results: The results of this study suggest that topical application of SS for 2 weeks significantly increases wound closure compared with the negative control. Moreover, treatment with SS significantly improved the pathological status of the wound throughout the protocol. There was also a significant decrease in malondialdehyde activity and increase in cytokine release in SS-treated rats compared with control rats.Conclusions: The results show that topical application of SS after inflicting second-degree burns in rats results in increased wound healing and decreased cytokine release and oxidative stress.Keyword: Spatholobus suberectus, Burns, Wound, Lipid peroxidation, Cytokines
Highlights
Burn injuries are commonly encountered in primary and emergency care settings worldwide [1]
Wound measurement was performed on days 1, 4, 7 and 14 after burn induction
There was a significant (p < 0.01) increase in wound closure on days 4, 7, 11 and 14 after burn induction compared with negative control group
Summary
Burn injuries are commonly encountered in primary and emergency care settings worldwide [1]. 1.5 % of the global population experiences a burn each year, and many suffer from long-lasting effects such as scarring. Chemicals and electricity can all result in burns and in the development of various complex symptoms via immune response activation. Previous studies suggest that infection control, pulmonary care, wound care and nutrition help improve recovery after a burn [2,3,4]. Povidone iodine, mafenide acetate and silver sulfadiazine creams and ointments are available topically to improve wound healing after a burn [5,6,7]. There are still challenges to treating and healing burn wounds
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