Abstract

Objective To explore the effect of SOX13 antibody(sry related HMG box 13-antibody, SOX13-Ab)on islet β cell function and to further determine the characteristics of autoimmune response of SOX13-Ab in ketosis-prone diabetes(KPD). Methods During the period from January 2005 to November 2009, the 245 KPD patients (male: 138, female: 107; age: 33(1.0 to 80.0)years) who visited a doctor in Department of Endocrinology at Nanjing Drum Tower Hospital were recruited and screened for SOX13-Ab, GDA-Ab and IA-2A. Then according to SOX13-Ab, GAD-Ab and IA-2A status, the diabetes were divided into SOX13-Ab, GAD-Ab, IA-2A positive groups and antibody-negative group. The effect of SOX13-Ab on islet β cell function was evaluated by comparison of C-peptide levels among the four subgroups. The mean levels of C-peptide in different subgroups were expressed as median(IQR), then analysed with ANOVA after being ln-transformed. Results The fasting C-peptide(FCP)and/or postprandial C-peptide(PCP)levels in SOX13-Ab or GAD-Ab positive groups were significantly lower than that in antibody-negative group among female KPD (FCP: 166.0(300.0)vs 287.5(302.7)pmol/L, 166.5(159.3)vs 287.5(302.7)pmol/L; PCP: 285.0(527.0)vs 528.0(774.0)pmol/L, 231.0(502.5)vs 528.0(774.0)pmol/L, all P 5 years, the levels of FCP in GAD-Ab positive group were significantly lower than that in SOX13-Ab positive group (130.0(458.8)vs 189.5(357.7)pmol/L, P<0.05). The comparison of β cell function among groups with different islet antibody status was made using an ANOVA model, which showed that no significant difference in FCP and PCP levels between SOX13-Ab positive and antibody-negative group, while the difference in FCP levels was significant between GAD-Ab/SOX13-Ab positive and antibody-negative group. There was significantly adverse relationship between duration and β cell function in KPD patients positive for GAD-Ab or IA-2A(GAD-Ab: r=-0.500, P=0.007; IA-2A: r=-0.821, P=0.023), while in KPD patients positive for SOX13-Ab, there was no significantly adverse relationship between duration and β cell function(r=-0.104, P=0.606). Conclusions The effect of SOX13-Ab is less marked than that of GAD-Ab on β cell function in KPD patients. Key words: SOX13 antibody; Ketosis-prone diabetes; Islet β cell function

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