Abstract
Cypermethrin, a Type II pyrethroid pesticide is commonly used in agriculture and many other domestic applications for pest control. Studies have shown that cypermethrin induces lipid peroxidation and alters the antioxidant status in non-target organisms. Fenugreek, a source of several polyphenols and flavonoids is a potent antioxidant. Hence in the present study we have investigated the possible effect of germinated fenugreek extract supplementation in counteracting the cypermethrin induced oxidative stress in erythrocytes of rats. Male Wistar rats were treated with 25 mg/kg weight (1/10 LD50) of cypermethrin and aqueous extract of germinated fenugreek (GFaq) (10%) for 60 days. Our results show that lipid peroxidation, an index of oxidative stress, significantly increased in circulation in cypermethrin-treated rats. The activities of SOD, CAT, GPx, GST in RBCs also decreased concomitantly in the cypermethrin treated rats. Treatment with aqueous extract of germinated fenugreek brought the values to near normal showing that fenugreek ameliorates cypermethrin-induced oxidative stress. HPLC analysis of the aqueous extract of germinated fenugreek showed the presence of flavonoids.© 2010 International Formulae Group. All rights reserved.Keywords: Cypermethrin, fenugreek, antioxidants, lipid peroxidation, oxidative stress, flavonoids
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